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Contributor Information

  • Name Martin Humphries
  • Institute University of Manchester

Tool Details

  • Tool name: Anti-CD49b [16B4]
  • Alternate names: Integrin Subunit Alpha 2; Alpha 2 Subunit Of VLA-2 Receptor; Platelet Membrane Glycoprotein Ia; CD49 Antigen-Like Family Member B; Collagen Receptor; CD49B; GPIa; Very Late Activation Protein 2 Receptor; Alpha-2 Subunit; Human Platelet Alloantigen System; Platelet Glycoprotein GPIa; VLA-2 Subunit Alpha; CD49b Antigen; HPA-5; VLA-2; VLAA2; BR
  • Clone: 16B4
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; FACS ; IHC ; IF ; IP
  • Description: CD49b is an integrin alpha subunit which makes up half of the Î?2Î?1 integrin duplex. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells (the NKT cells), NK cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling.
  • Immunogen: Purified human beta 1 preparation from HT1080 fibrosarcoma cell extract.
  • Isotype: IgG1
  • Research area: Cell biology; Cell signaling and signal transduction; Immunology
  • Myeloma used: P3X63Ag8.653

  • For Research Use Only

Target Details

  • Target: CD49f (Integrin a2+b1)
  • Target background: CD49b is an integrin alpha subunit which makes up half of the a2?1 integrin duplex. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells (the NKT cells), NK cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling.

Application Details

  • Application: ELISA ; FACS ; IHC ; IF ; IP

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Suarez et al. 2015. Arch Dermatol Res. 307(2):115-33. PMID: 25322916.
  • •  Menhofer et al. 2014. Cardiovasc Res. 104(2):303-14. PMID: 25239826.
  • •  Identification of biomarkers involved in differential profiling of hypertrophic and keloid scars versus normal skin.
  • •  In vitro and in vivo characterization of the actin polymerizing compound chondramide as an angiogenic inhibitor.
  • •  Tuckwell et al. 2000. Biochem J. 350 Pt 2:485-93. PMID: 10947963.
  • •  Monoclonal antibodies identify residues 199-216 of the integrin alpha2 vWFA domain as a Fnly important region within alpha2beta1.
  • •  Sincock et al. 1999. J Cell Sci. 112 ( Pt 6):833-44. PMID: 10036233.
  • •  PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function.
  • •  Fitter et al. 1999. Biochem J. 338 ( Pt 1):61-70. PMID: 9931299.
  • •  Transmembrane 4 superfamily protein CD151 (PETA-3) associates with beta 1 and alpha IIb beta 3 integrins in haemopoietic cell lines and modulates cell-cell adhesion.