Product Image

Contributor Information

  • Institute Ludwig Institute for Cancer Research

Tool Details

  • Tool name: Anti-MAGE-1 [MA454]
  • Alternate names: MAGE Family Member A1; Melanoma-Associated Antigen MZ2-E; Cancer/Testis Antigen 1.1; Melanoma Antigen MAGE-1; MAGE-1 Antigen; Antigen MZ2-E; CT1.1; Cancer/Testis Antigen Family 1; MAGE1A
  • Clone: MA454
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: IHC ; WB
  • Description: Human malignant neoplasms carry rejection antigens that are recognized by the patients autologous, tumor directed and specific, cytolytic, CD8+T lymphocyte clones (CTL). An important group of antigens is coded by the MAGE family of genes. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.
  • Isotype: IgG1
  • Research area: Cancer ; Cell Type or Organelle Marker

  • For Research Use Only

Target Details

  • Target: MAGE-1
  • Target background: Human malignant neoplasms carry rejection antigens that are recognized by the patients autologous, tumor directed and specific, cytolytic, CD8+T lymphocyte clones (CTL). An important group of antigens is coded by the MAGE family of genes. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.

Application Details

  • Application: IHC ; WB

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

Related Tools

Product Image

Anti-CD-45 [C455.1F]

#155248
Product Image

Anti-IgD [Z72P1E9*A4]

#153473
Product Image

Anti-Calcineurin [BF1.1]

#151536

References

  • •  Chen et al. 1994. Proc Natl Acad Sci U S A. 91(3):1004-8. PMID: 8302824.