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Contributor Information

  • Name Ayham Alnabulsi
  • Institute Vertebrate Antibodies Limited

Tool Details

  • Tool name: Anti-Cytochrome P450 2A6, 2A7, 2A13 [F16 P2 D8]
  • Clone: F16 P2 D8
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; IHC ; WB
  • Strain: Balb/c
  • Description: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
  • Immunogen: ovalbumin-conjugated synthetic peptide RNYTMSFLPR. CYP2A6, CYP2A7and CYP2A13 have the same c-terminal sequence. (C-terminal sequence identical in human and rhesus macaque)
  • Isotype: IgG1 kappa
  • Research area: Cancer; Tissue-specific biology; Cell signaling and signal transduction; Metabolism

  • For Research Use Only

Target Details

  • Target: Cytochrome P450 2A6, 2A7and 2A13 (CYP2A6, CYP2A7, CYP2A13)
  • Target background: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Application Details

  • Application: ELISA ; IHC ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   Murray et al. 2010. Histopathology. 57(2):202-11. PMID: 20716162.
  •   Profiling the expression of cytochrome P450 in breast cancer.
  •   Downie et al. 2005. Clin Cancer Res. 11(20):7369-75. PMID: 16243809.
  •   Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers.
  •   Kumarakulasingham et al. 2005. Clin Cancer Res. 11(10):3758-65. PMID: 15897573.
  •   Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis.