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Contributor Information

  • Name Ayham Alnabulsi
  • Institute Vertebrate Antibodies Limited

Tool Details

  • Tool name: Anti-Cytochrome P450 51A1 [N6-P2H5*G8]
  • Clone: N6-P2H5*G8
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; IHC ; WB
  • Description: Cytochrome P450, family 51, subfamily A, polypeptide 1 (CYP51A1) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP51A1 is an endoplasmic reticulum protein that participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol.
  • Immunogen: Ovalbumin-conjugated synthetic peptide NPVIRYKRRS (C-terminal sequence).
  • Isotype: IgG1 kappa
  • Research area: Cancer; Tissue-specific biology; Cell signaling and signal transduction; Metabolism
  • Myeloma used: P3X63Ag8.653

  • For Research Use Only

Target Details

  • Target: CYP51A1- Cytochrome P450, family 51, subfamily A, polypeptide 1.
  • Target background: Cytochrome P450, family 51, subfamily A, polypeptide 1 (CYP51A1) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP51A1 is an endoplasmic reticulum protein that participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol.

Application Details

  • Application: ELISA ; IHC ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Characterisation of the oxysterol metabolising enzyme pathway in mismatch repair proficient and deficient colorectal cancer.
  • •  Swan et al. 2016. Oncotarget. :. PMID: 27341022.