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Contributor Information

  • Name Heike Laman
  • Institute University College London (UCL)

Tool Details

  • Tool name: Anti-Fbxo7 [HLA3]
  • Clone: HLA3
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Polyclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Mouse
  • Host: Rabbit
  • Molecular weight of the target: ~59/~70 kDa
  • Application: IHC ; IP ; WB
  • Description: Recessive mutations in FBXO7/PARK15 cause an atypical EOPD. In certain cancers, the protein is highly expressed. These cell lines all express Fbxo7: U2OS, SHSY5Y, HEK293, Jurkat, SKOV3, HeLa, Ba-F3, Nalm6, C33A, MEL, HSPCs, MEFs.
  • Immunogen: aa 499-522 of human Fbxo7 synthetic peptide coupled to KLH
  • Research area: Cell biology; Genetics

  • For Research Use Only

Target Details

  • Target: Fbxo7
  • Target molecular weight: ~59/~70 kDa
  • Target background: Recessive mutations in FBXO7/PARK15 cause an atypical EOPD. In certain cancers, the protein is highly expressed. These cell lines all express Fbxo7: U2OS, SHSY5Y, HEK293, Jurkat, SKOV3, HeLa, Ba-F3, Nalm6, C33A, MEL, HSPCs, MEFs.

Application Details

  • Application: IHC ; IP ; WB

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Burchell et al. 2013. Nat Neurosci. 16(9):1257-65. PMID: 23933751.
  • •  The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.
  • •  Meziane el et al. 2011. J Cell Sci. 124(Pt 13):2175-86. PMID: 21652635.
  • •  Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells.
  • •  Laman et al. 2005. EMBO J. 24(17):3104-16. PMID: 16096642.
  • •  Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.