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Contributor Information

  • Name Ayham Alnabulsi
  • Institute Vertebrate Antibodies Limited

Tool Details

  • Tool name: Anti-FANCM [M40-P2C6]
  • Alternate names: Fanconi Anemia Complementation Group M; KIAA1596; Fanconi Anemia-Associated Polypeptide Of 25 Kda; ATP-Dependent RNA Helicase FANCM; Protein Hef Ortholog; FAAP25
  • Clone: M40-P2C6
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; IF ; WB
  • Strain: Balb/c
  • Description: Fanconi Anemia, Complementation Group M (FANC-M) is an ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair that binds to ssDNA but not to dsDNA. Mutations in the FANCM are associated with Fanconi anemia, a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. Mutations in the Fanconi anemia DNA repair pathway have been implicated in familial breast cancer risk.
  • Immunogen: Peptide Sequence - MLPNDLNQDR (amino acids 2069 -2078)
  • Isotype: IgG1 kappa
  • Research area: Genetics
  • Myeloma used: P3X63Ag8.653

  • For Research Use Only

Target Details

  • Target: Fanconi Anemia, Complementation Group M (FANC-M)
  • Target background: Fanconi Anemia, Complementation Group M (FANC-M) is an ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair that binds to ssDNA but not to dsDNA. Mutations in the FANCM are associated with Fanconi anemia, a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. Mutations in the Fanconi anemia DNA repair pathway have been implicated in familial breast cancer risk.

Application Details

  • Application: ELISA ; IF ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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