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Contributor Information

  • Name Michael Matunis
  • Institute Johns Hopkins University

Tool Details

  • Tool name: Anti-SUMO-2/SUMO-3 (8A2)
  • Alternate names: Small ubiquitin-related modifier 2; HSMT3; SMT3 homolog 2; SUMO-3; Zentrin-2; Ubiquitin-like protein SMT3B; Smt3B
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ChIP ; IHC ; IF ; IP ; WB
  • Description: Small ubiquitin-like modifiers (SUMO) post-translationally modify proteins by a process called SUMOylation. There are three SUMO proteins expressed in vertebrates, SUMO-2 and SUMO-3 are ~95% identical to each other (SUMO-2/3), but they are only ~45% identical to SUMO-1. Consequently, SUMO-2/3 have unique targets and functions compared to SUMO-1. For instances SUMO-2/3 can form polymeric chains and SUMO-1 cannot. SUMOylation on lysine residues regulates various cellular processes including nuclear transport, DNA replication and repair, transcription, protein stability, mitochondrial fission, signal transduction, mitosis and apoptosis.
  • Immunogen: Full length human recombinant protein of SUMO-2
  • Isotype: IgG
  • Research area: Apoptosis and autophagy; Cell biology; Cell signaling and signal transduction; Genetics; Biochemistry

  • For Research Use Only

Target Details

  • Target: SUMO-2 and SUMO-3 but does not recognize SUMO-1
  • Target background: Small ubiquitin-like modifiers (SUMO) post-translationally modify proteins by a process called SUMOylation. There are three SUMO proteins expressed in vertebrates, SUMO-2 and SUMO-3 are ~95% identical to each other (SUMO-2/3), but they are only ~45% identical to SUMO-1. Consequently, SUMO-2/3 have unique targets and functions compared to SUMO-1. For instances SUMO-2/3 can form polymeric chains and SUMO-1 cannot. SUMOylation on lysine residues regulates various cellular processes including nuclear transport, DNA replication and repair, transcription, protein stability, mitochondrial fission, signal transduction, mitosis and apoptosis.

Application Details

  • Application: ChIP ; IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Storage conditions: -20°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Zhang et al. 2008. Mol Cell. 29(6):729-41. PMID: 18374647.
  • •  SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis.