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Contributor Information

  • Name Ayham Alnabulsi
  • Institute Vertebrate Antibodies Limited

Tool Details

  • Tool name: Anti-Cytochrome P450 4V2 [M29-P3B10]
  • Alternate names: Cytochrome P45; Family 4; Subfamily V; Polypeptide 2; Docosahexaenoic Acid Omega-Hydroxylase CYP4V2; CYP4AH1; BCD
  • Clone: M29-P3B10
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; IHC ; WB
  • Strain: Balb/c
  • Description: Cytochrome P450, family 4, subfamily V, polypeptide 2 (CYP4V2) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP4V2 catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. CYP4V2 may have a role in fatty acid and steroid metabolism in the eye and its mutations are associated with Bietti's crystalline dystrophy (BCD) and retinitis pigmentosas.
  • Immunogen: Peptide sequence KREELGLEGQ (amino acids 495 504)
  • Isotype: IgG1 kappa
  • Research area: Cancer; Tissue-specific biology; Cell signaling and signal transduction; Metabolism
  • Myeloma used: P3X63Ag8.653

  • For Research Use Only

Target Details

  • Target: Cytochrome P450, family 4, subfamily V, polypeptide 2 (CYP4V2)
  • Target background: Cytochrome P450, family 4, subfamily V, polypeptide 2 (CYP4V2) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP4V2 catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. CYP4V2 may have a role in fatty acid and steroid metabolism in the eye and its mutations are associated with Bietti's crystalline dystrophy (BCD) and retinitis pigmentosas.

Application Details

  • Application: ELISA ; IHC ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Alnabulsi et al. 2017. Br J Cancer. :. PMID: 28557975.
  • •  The differential expression of omega-3 and omega-6 fatty acid metabolising enzymes in colorectal cancer and its prognostic significance.
  • •  Alnabulsi et al. 2016. Characterisation of Arachidonic Acid Metabolising Enzymes in Colorectal Cancer. J Pathol. 240 Suppl 1:S1-S48. PMID: 27747872
  • •  Nottingham Pathology 2016. 9th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 28 June - 1 July 2016.