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Contributor Information

  • Name Ming-Qing Du
  • Institute University College London (UCL)

Tool Details

  • Tool name: Anti-BCL10 [151]
  • Clone: 151
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; IHC ; WB
  • Strain: Balb/c
  • Description: BCL-10 is an apoptotic regulatory molecule, of approximately 31 kDa. It was identified through its direct involvement in t(1:14) (p22;q32) of mucosa-associated lymphoid tissue (MALT) lymphoma. In B-cell follicles, BCL10 has been shown to be expressed abundantly in the germinal center B cells, moderately in the marginal zone, but only weakly in mantle zone B cells. This differential expression is an indicator of its importance in maturation and malignant transformation of human B-cells. BCL-10 contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB.
  • Immunogen: Full-length recombinant BCL-10 protein
  • Isotype: IgG1 kappa
  • Research area: Apoptosis and autophagy; Cancer; Cell signaling and signal transduction; Metabolism
  • Myeloma used: NS0

  • For Research Use Only

Target Details

  • Target: Bcl10
  • Target background: BCL-10 is an apoptotic regulatory molecule, of approximately 31 kDa. It was identified through its direct involvement in t(1:14) (p22;q32) of mucosa-associated lymphoid tissue (MALT) lymphoma. In B-cell follicles, BCL10 has been shown to be expressed abundantly in the germinal center B cells, moderately in the marginal zone, but only weakly in mantle zone B cells. This differential expression is an indicator of its importance in maturation and malignant transformation of human B-cells. BCL-10 contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB.

Application Details

  • Application: ELISA ; IHC ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Shen et al. 2003. Blood. 102(4):1553-4. PMID: 12900354.
  • •  Aberrant BCL10 nuclear expression in nasal NK/T-cell lymphoma.
  • •  Ye et al. 2000. Am J Pathol. 157(4):1147-54. PMID: 11021819.
  • •  BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma.
  • •  Du et al. 2000. Blood. 95(12):3885-90. PMID: 10845924.
  • •  BCL10 gene mutation in lymphoma.