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Contributor Information

  • Name Birgit Lane
  • Institute University of Dundee

Tool Details

  • Tool name: Anti-Keratin18 [LDK18]
  • Clone: LDK18
  • Tool type: Antibodies
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Mouse ; Pig
  • Host: Mouse
  • Application: ELISA ; FACS ; IHC ; IF ; IP ; WB
  • Description: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 8 and 18 are two of the first keratins expressed in the embryo, and persist into adult tissues as the keratin pair representing minimal epithelial keratin expression. Keratins 8 and 18 are major components of all simple epithelia (but not of stratified squamous epithelia) and adenocarcinomas.
  • Immunogen: Synthetic peptide of human keratin 18 (CSETNDTKVLRH-COOH)
  • Isotype: IgG1 kappa
  • Research area: Cell signaling and signal transduction

  • For Research Use Only

Target Details

  • Target: Keratin 18
  • Target background: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 8 and 18 are two of the first keratins expressed in the embryo, and persist into adult tissues as the keratin pair representing minimal epithelial keratin expression. Keratins 8 and 18 are major components of all simple epithelia (but not of stratified squamous epithelia) and adenocarcinomas.

Application Details

  • Application: ELISA ; FACS ; IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1mg/ml
  • Storage buffer: DMEM + 5% FCS
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Hosoya A et al. Anat Rec (Hoboken). 2010 Nov
  • •  293(11):1864-72. PMID: 20818615 D'Alessandro M et al. J Invest Dermatol. 2011 Jul
  • •  131(7):1412-9. PMID: 21326298