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Contributor Information

  • Name Jacqueline Cordell
  • Institute University of Oxford

Tool Details

  • Tool name: Anti-CD19 [LC-1/32/A10]
  • Alternate names: CD19 Molecule; B-Lymphocyte Surface Antigen B4; T-Cell Surface Antigen Leu-12; Differentiation Antigen CD19; CD19 Antigen; CVID3; B4
  • Clone: LC-1/32/A10
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: IHC ; WB
  • Description: CD19 is a cell surface molecule expressed on B lymphocytes and follicular dendritic cells. It is expressed by most pre-B cells and by the majority of non-T-cell acute lymphocytic leukaemias and B-cell type chronic lymphocytic leukaemias. CD19 assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
  • Immunogen: A synthetic peptide, corresponding to the C-Terminus of CD19.
  • Isotype: IgG1 kappa
  • Research area: Cancer; Cell signaling and signal transduction; Immunology; Stem cell biology
  • Myeloma used: NS0

  • For Research Use Only

Target Details

  • Target: CD19
  • Target background: CD19 is a cell surface molecule expressed on B lymphocytes and follicular dendritic cells. It is expressed by most pre-B cells and by the majority of non-T-cell acute lymphocytic leukaemias and B-cell type chronic lymphocytic leukaemias. CD19 assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

Application Details

  • Application: IHC ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -20°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Carter et al. 1992. Science. 256(5053):105-7. PMID: 1373518.
  • •  CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes.
  • •  Tedder et al. 1989. J Immunol. 143(2):712-7. PMID: 2472450.
  • •  Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily.