ANTIBODIES
Contributor Information
- Institute A*STAR Accelerate Technologies Pte Ltd
Tool Details
- Tool name: Anti-VTN2 [1A5]
- Clone: 1A5
- Tool type: Antibodies
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human ; Zebrafish
- Host: Mouse
- Application: IF ; WB
- Description: NF-ÄÂ?B (nuclear factor kappaB) is a transcription factor that activates numerous target genes important in mediating innate and adaptive immunity in mammals. Activation by external stimuli such as TNF leads to the activation of kinases (IKK1 and IKK2) that phosphorylate inhibitory proteins I-ÄÂ?B and their subsequent degradation. IKK1 and IKK2 form the catalytic subunits of a complex which includes IKKÄÂ?, the regulatory component (also known as NEMO). Mutations in NEMO are the cause of the human disorders incontinentia pigmenti and ectodermal dysplasia (ED-AID).
- Immunogen: GST/His-tagged splice variant of Zebrafish IKK? protein of 154 amino acids fusion protein
- Isotype: IgG1
- Research area: Genetics; Biochemistry
- Myeloma used: Sp2/0-Ag14
- For Research Use Only
Target Details
- Target: Splice variant of Zebrafish IKKg protein (154 amino acids)
- Target background: NF-ÄÂ?B (nuclear factor kappaB) is a transcription factor that activates numerous target genes important in mediating innate and adaptive immunity in mammals. Activation by external stimuli such as TNF leads to the activation of kinases (IKK1 and IKK2) that phosphorylate inhibitory proteins I-ÄÂ?B and their subsequent degradation. IKK1 and IKK2 form the catalytic subunits of a complex which includes IKKÄÂ?, the regulatory component (also known as NEMO). Mutations in NEMO are the cause of the human disorders incontinentia pigmenti and ectodermal dysplasia (ED-AID).
Application Details
- Application: IF ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15Ă°C to -25Ă°C
- Shipping conditions: Shipping at 4Ă°C
Documentation
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