ANTIBODIES
Contributor Information
- Name Tasneem Ritchie
- Institute University of Oxford
Tool Details
- Tool name: Anti-Codanin1 [Cod177]
- Alternate names: Codanin 1; Congenital Dyserythropoietic Anemia; Type I; Discs Lost Homolog; PRO1295; CDAN1A; CDA1; DLT
- Clone: Cod177
- Tool type: Antibodies
- Tool sub-type: Primary Antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human ; Mouse
- Host: Mouse
- Application: IF ; WB
- Description: Codanin-1 may act as a negative regulator of histone chaperone anti-silencing function 1 (ASF1) in chromatin assembly. Mutations in the codanin-1 gene cause congenital dyserythropoietic anemia 1 (CDA1), which is an autosomal recessive blood disorder characterised by morphological abnormalities of erythroblasts, ineffective erythropoiesis, macrocytic anemia and secondary hemochromatosis.
- Immunogen: aa 294-607 of cloned human protein
- Isotype: IgG2b
- Research area: Tissue-specific biology
- Myeloma used: NS0
- For Research Use Only
Target Details
- Target: Codanin
- Target background: Codanin-1 may act as a negative regulator of histone chaperone anti-silencing function 1 (ASF1) in chromatin assembly. Mutations in the codanin-1 gene cause congenital dyserythropoietic anemia 1 (CDA1), which is an autosomal recessive blood disorder characterised by morphological abnormalities of erythroblasts, ineffective erythropoiesis, macrocytic anemia and secondary hemochromatosis.
Application Details
- Application: IF ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15Ă°C to -25Ă°C
- Shipping conditions: Shipping at 4Ă°C
Documentation
References
- • Renella et al. 2011. Blood. 117(25):6928-38. PMID: 21364188.
- • Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1{alpha} localization in erythroblasts.
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