ANTIBODIES
Contributor Information
- Name Roland Wolf
- Institute University of Dundee
Tool Details
- Tool name: Anti-Cytochrome P450 3A4 [CYP3A4]
- Clone: CYP3A4
- Tool type: Antibodies
- Tool sub-type: Primary Antibody
- Class: Polyclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Sheep
- Application: WB
- Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1.
- Immunogen: Purified recombinant human P450s
- Research area: Tissue-specific biology; Cell signaling and signal transduction; Genetics; Metabolism
- For Research Use Only
Target Details
- Target: CYP 3A4
- Target background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1.
Application Details
- Application: WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Storage conditions: -15°C to -25°C
- Shipping conditions: Shipping at 4°C
Documentation
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