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Contributor Information

  • Name Geoff Toms
  • Institute Newcastle University

Tool Details

  • Tool name: Anti-Metapneumovirus Fusion Protein [hMPV24]
  • Clone: hMPV24
  • Tool type: Antibodies
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Virus
  • Host: Mouse
  • Application: IHC; IF ; WB
  • Strain: Balb/c
  • Description: Monoclonal antibody which can identify human metapneumovirus via immunofluorescent staining and does not cross react to other cell cultures Background and Research Application Anti-hMPV monoclonal antibody which can identify and locate the fusion glycoprotein of human metapneumovirus (hMPV) of both types A and B, within a sample. hMPV is a negative single stranded RNA virus of the paramyxoviridae family and can cause upper and lower respiratory tract infections. Discovered in 2001, there appear to be 4 lineages of the hMPV virus, stemming from sub-groups A and B.Anti-hMPV24 can recognise the fusion protein of all 4 lineages(A1,A2, B1 and B2). Anti-hMPV24 be also used in conjunction with other hMPV antibody clones to detect all strains of the virus. Anti-hMPV24 was created to diagnose hMPV infection in respiratory specimens via immunofluorescence staining with optimal staining of clinical samples with low backgrounds on uninfected specimens.
  • Immunogen: Human MPV strain NCL-145
  • Isotype: IgG2a kappa
  • Research area: Microbiology
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: Metapneumovirus Fusion Protein
  • Target background: Monoclonal antibody which can identify human metapneumovirus via immunofluorescent staining and does not cross react to other cell cultures Background and Research Application Anti-hMPV monoclonal antibody which can identify and locate the fusion glycoprotein of human metapneumovirus (hMPV) of both types A and B, within a sample. hMPV is a negative single stranded RNA virus of the paramyxoviridae family and can cause upper and lower respiratory tract infections. Discovered in 2001, there appear to be 4 lineages of the hMPV virus, stemming from sub-groups A and B.Anti-hMPV24 can recognise the fusion protein of all 4 lineages(A1,A2, B1 and B2). Anti-hMPV24 be also used in conjunction with other hMPV antibody clones to detect all strains of the virus. Anti-hMPV24 was created to diagnose hMPV infection in respiratory specimens via immunofluorescence staining with optimal staining of clinical samples with low backgrounds on uninfected specimens.

Application Details

  • Application: IHC; IF ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: RPMI + Hepes (25mM) + glutamine (2mM) + 10% heat inactivated FCS.
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Fenwick F. et al. 2007. J Clin Virol. 40:193-6. PMID: 17869169 Tedcastle AB. et al. 2012. J Med Virol. 84(7):1061-70.PMID: 22585723