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Contributor Information

  • Name Madalena Tarsounas
  • Institute Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details

  • Tool name: Anti-BRCA2 [MTA42]
  • Alternate names: BRCA 2, BRCA1/BRCA2 containing complex subunit 2, Brca2, BRCA2_HUMAN, BRCC 2, BRCC2, Breast and ovarian cancer susceptibility gene early onset, Breast cancer 2 early onset, Breast Cancer 2 tumor suppressor, Breast cancer susceptibility protein BRCA2, Breast cancer type 2 susceptibility protein, BROVCA2, FACD, FAD 1, FAD, FAD1, FANCB, FANCD 1
  • Clone: MTA42
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Polyclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Mouse
  • Host: Rabbit
  • Cancer type: Breast cancer; Gynaecologic cancer;
  • Molecular weight of the target: 370 kDa
  • Application: ChIP ; IP ; WB
  • Description: Breast Cancer Type 2 susceptibility protein (BRCA2) is a tumour suppressor gene. BRCA2 is involved in the repair of chromosomal damage, specifically in localising Rad51 to double strand breaks. BRCA2 and BRCA1 are frequently mutated in cases of hereditary breast and ovarian cancer.
  • Immunogen: Human BRCA2 sequence
  • Research area: Cancer; Genetics

  • For Research Use Only

Target Details

  • Target: BRCA2
  • Target molecular weight: 370 kDa
  • Target background: Breast Cancer Type 2 susceptibility protein (BRCA2) is a tumour suppressor gene. BRCA2 is involved in the repair of chromosomal damage, specifically in localising Rad51 to double strand breaks. BRCA2 and BRCA1 are frequently mutated in cases of hereditary breast and ovarian cancer.

Application Details

  • Application: ChIP ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1.47 mg/ml
  • Storage buffer: PBS, 0.1% NaN3
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   Zhang et al. 2012. Clin Cancer Res. 18(21):5961-71. PMID: 22977194.
  •   FoxM1 inhibition sensitizes resistant glioblastoma cells to temozolomide by downregulating the expression of DNA-repair gene Rad51.
  •   Badie et al. 2010. Nat Struct Mol Biol. 17(12):1461-9. PMID: 21076401.
  •   BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping.