ANTIBODIES

Contributor Information
- Name Madalena Tarsounas
- Institute Cancer Research UK, London Research Institute: Clare Hall Laboratories
Tool Details
- Tool name: Anti-POT1 [MTA40]
- Clone: MTA40
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Polyclonal
- Conjugate: Unconjugated
- Reactivity: Human ; Mouse
- Host: Rabbit
- Molecular weight of the target: 70 kDa
- Application: IP ; WB
- Description: POT1 (protection of telomeres 1) is part of the telomerase ribonucleotide (RNP) complex, which stabilises chromosomes by controlling telomere elongation. POT1 is a component of the double-stranded telomeric DNA-binding TRF1 complex which cis-inhibits telomerase. POT1 localization on telomeres diminishes in the absence of single-stranded DNA.
- Immunogen: Full-length human POT1 protein
- Research area: Cancer; Genetics
- For Research Use Only
Target Details
- Target: POT1
- Target molecular weight: 70 kDa
- Target background: POT1 (protection of telomeres 1) is part of the telomerase ribonucleotide (RNP) complex, which stabilises chromosomes by controlling telomere elongation. POT1 is a component of the double-stranded telomeric DNA-binding TRF1 complex which cis-inhibits telomerase. POT1 localization on telomeres diminishes in the absence of single-stranded DNA.
Application Details
- Application: IP ; WB
Handling
- Format: Liquid
- Concentration: 1.5 mg/ml
- Storage buffer: PBS, 0.1% NaN3
- Storage conditions: -15ðC to -25ðC
- Shipping conditions: Shipping at 4ðC
Related Tools
References
- • Martinez et al. 2010. Nat Cell Biol. 12(8):768-80. PMID: 20622869.
- • Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites.
- • Mart
nez et al. 2009. Genes Dev. 23(17):2060-75. PMID: 19679647. - • Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice.