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Contributor Information

  • Name Madalena Tarsounas
  • Institute Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details

  • Tool name: Anti-POT1 [MTA40]
  • Clone: MTA40
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Polyclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Mouse
  • Host: Rabbit
  • Molecular weight of the target: 70 kDa
  • Application: IP ; WB
  • Description: POT1 (protection of telomeres 1) is part of the telomerase ribonucleotide (RNP) complex, which stabilises chromosomes by controlling telomere elongation. POT1 is a component of the double-stranded telomeric DNA-binding TRF1 complex which cis-inhibits telomerase. POT1 localization on telomeres diminishes in the absence of single-stranded DNA.
  • Immunogen: Full-length human POT1 protein
  • Research area: Cancer; Genetics

  • For Research Use Only

Target Details

  • Target: POT1
  • Target molecular weight: 70 kDa
  • Target background: POT1 (protection of telomeres 1) is part of the telomerase ribonucleotide (RNP) complex, which stabilises chromosomes by controlling telomere elongation. POT1 is a component of the double-stranded telomeric DNA-binding TRF1 complex which cis-inhibits telomerase. POT1 localization on telomeres diminishes in the absence of single-stranded DNA.

Application Details

  • Application: IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1.5 mg/ml
  • Storage buffer: PBS, 0.1% NaN3
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   Martinez et al. 2010. Nat Cell Biol. 12(8):768-80. PMID: 20622869.
  •   Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites.
  •   Martnez et al. 2009. Genes Dev. 23(17):2060-75. PMID: 19679647.
  •   Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice.