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Contributor Information

  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-TFF1 [PS2GE1]
  • Clone: PS2GE1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 6.5 kDa
  • Application: IHC ; IP
  • Strain:
  • Description: pS2 is a cysteine-rich, 6.5kDa protein found in both oestrogen-dependent (breast tumours) and oestrogen-independent tissues (normal stomach mucosa). About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localisation to the Golgi apparatus. pS2 is primarily expressed in oestrogen receptor-positive breast tumours.
  • Immunogen: A synthetic 31-mer peptide from the C-terminus of human pS2 protein
  • Isotype: IgG1
  • Research area: Cancer; Cell biology; Genetics

  • For Research Use Only

Target Details

  • Target: Trefoil factor 1 (TFF1) also known as pS2/pNR2 Estrogen-regulated protein Ab2
  • Target molecular weight: 6.5 kDa
  • Target background: pS2 is a cysteine-rich, 6.5kDa protein found in both oestrogen-dependent (breast tumours) and oestrogen-independent tissues (normal stomach mucosa). About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localisation to the Golgi apparatus. pS2 is primarily expressed in oestrogen receptor-positive breast tumours.

Application Details

  • Application: IHC ; IP

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Williams et al. 1996. Hum Pathol. 27(12):1259-66. PMID: 8958295.
  • •  Characterization of monoclonal antibodies raised to C-terminal peptides of pS2: a major trefoil peptide and motility factor expressed in adenocarcinomas and regions of mucosal injury.