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Contributor Information

  • Name Melanie Hardman
  • Institute Cancer Research Technology

Tool Details

  • Tool name: Anti-SNAIL1 [20C8]
  • Clone: 20C8
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Cancer type: Breast cancer; Genitourinary cancer; Gynaecologic cancer; Carcinoma
  • Application: WB ; ChIP ; ELISA ; IHC ; IF ; IP ; WB
  • Description: The Snail superfamily are zinc finger transcription factors. Overexpression of Snail1 can lead to cells undergoing EMT (epithelial to mesenchymal transition). This is achieved as Snail1 represses expression of E-cadherin, desmoplakin, muc-1, cytokeratin18 while enhances expression of vimentin and fibronectin. Snail1 therefore has a strong association with metastatic disease.
  • Immunogen: Human Snail 1 recombinant protein
  • Isotype: IgG2a kappa
  • Research area: Cancer; Tissue-specific biology; Genetics

  • For Research Use Only

Target Details

  • Target: SNAIL1
  • Target background: The Snail superfamily are zinc finger transcription factors. Overexpression of Snail1 can lead to cells undergoing EMT (epithelial to mesenchymal transition). This is achieved as Snail1 represses expression of E-cadherin, desmoplakin, muc-1, cytokeratin18 while enhances expression of vimentin and fibronectin. Snail1 therefore has a strong association with metastatic disease.

Application Details

  • Application: WB ; ChIP ; ELISA ; IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Yang et al. 2018. Exp Mol Med. 50(1):e420. PMID: 29303507.
  • •  Goldman et al. 2016. Stem Cell Res. 17(1):62-8. PMID: 27240252.
  • •  Ju et al. 2015. Cell Death Dis. 6:e1801. PMID: 26136074.
  • •  Tuhkanen et al. 2009. BMC Cancer. 9:289. PMID: 19695091.
  • •  Nuclear expression of Snail1 in borderline and malignant epithelial ovarian tumours is associated with tumour progression.
  • •  Vincent et al. 2009. Nat Cell Biol. 11(8):943-50. PMID: 19597490.
  • •  A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition.
  • •  Franc et al. 2006. Oncogene. 25(37):5134-44. PMID: 16568079.
  • •  Expression of Snail protein in tumor-stroma interface.