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Contributor Information

  • Name Neil Perkins
  • Institute University of Dundee

Tool Details

  • Tool name: Anti-BCLAF1 [BCLAF1]
  • Clone: BCLAF1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Polyclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Rabbit
  • Application: IP ; WB
  • Description: BCL2-associated transcription factor 1 (BCLAF1), also known as BTF, is a 920 amino acid protein that localizes to both the nucleus and the cytoplasm. Overexpression of BCLAF1 promotes apoptosis by preventing the transcription of Bcl-2. Bcl-2 is one of many key regulators of apoptosis which are essential for development, tissue homeostasis and protection against foreign pathogens. Four isoforms of BCLAF1 exist due to alternative splicing events.
  • Immunogen: Recombinant His-tagged protein fragment of Human BCLAF1
  • Research area: Apoptosis and autophagy; Genetics

  • For Research Use Only

Target Details

  • Target: BCL2 Associated Transcription Factor 1 (BCLAF1)
  • Target background: BCL2-associated transcription factor 1 (BCLAF1), also known as BTF, is a 920 amino acid protein that localizes to both the nucleus and the cytoplasm. Overexpression of BCLAF1 promotes apoptosis by preventing the transcription of Bcl-2. Bcl-2 is one of many key regulators of apoptosis which are essential for development, tissue homeostasis and protection against foreign pathogens.

Application Details

  • Application: IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Bracken et al. 2008. Cancer Res. 68(18):7621-8. PMID: 18794151.
  • •  Regulation of cyclin D1 RNA stability by SNIP1.