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Contributor Information

  • Name John Marshall
  • Institute Queen Mary University of London

Tool Details

  • Tool name: Anti-Integrin aVb6 [AvB6 53a.2]
  • Clone: AvB6 53a.2
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Rat
  • Application: FACS ; IF ; IP ; Fn
  • Description: Monoclonal antibody involved in carcinoma invasion, with high potential as a therapeutic target.
  • Immunogen: Mouse fibroblasts retrovirally infected with cDNA to human beta6 (3T3b6.19). Cells expressed a mouse/human avb6 chimera.
  • Immunogen UniProt ID: P06756
  • Isotype: IgG2a
  • Research area: Cell biology; Cancer; Tissue-specific biology; Cell signaling and signal transduction; Stem cell biology

  • For Research Use Only

Target Details

  • Target: Integrin alpha v/beta 6
  • Target background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells and aberrant integrin expression has been found in many epithelial tumours. The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. Integrin alpha-v beta-6 is upregulated in cancers and during tissue remodelling but is absent from resting adult tissues. Integrin alpha-v beta-6 promotes carcinoma invasion, fibrosis and correlates with poor survival and therefore makes a promising therapeutic target. This antibody does not recognize alpha V or other alpha V integrins.

Application Details

  • Application: FACS ; IF ; IP ; Fn

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: Store at -20°C frozen. Avoid repeated freeze / thaw cycles
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Liu et al. 2017. Exp Ther Med. 14(4):3880-3886. PMID: 29042996.
  • •  Marsh et al. 2008. Cancer Res. 68(9):3295-303. PMID: 18451156.
  • •  alpha vbeta 6 Integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation.