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Contributor Information

  • Institute University of Cambridge

Tool Details

  • Tool name: Anti-RAET1E [RAET1E 50/3]
  • Clone: RAET1E 50/3
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target:
  • Application: ELISA ; FACS ; IF ; IP ; Fn ; WB
  • Description: RAET1E (Retinoic Acid Early Transcript 1E), or ULBP4, is a member of the RAET1 family of major histocompatibility complex (MHC) class I-related genes. RAET1E and RAET1G differ from the other RAET1 proteins by having a type I membrane-spanning sequence at their C termini rather than glycosylphosphatidylinositol anchor sequences. RAET1E is a functional ligand for NKG2D, which causes lymphocyte activation resulting in the secretion of cytokines.
  • Immunogen: Recombinant His-tagged protein to human extra-cellular domain of RAET1E, grown in E.coli
  • Isotype: IgG2b
  • Research area: Immunology

  • For Research Use Only

Target Details

  • Target: RAET1E
  • Target molecular weight:
  • Target background: RAET1E (Retinoic Acid Early Transcript 1E), or ULBP4, is a member of the RAET1 family of major histocompatibility complex (MHC) class I-related genes. RAET1E and RAET1G differ from the other RAET1 proteins by having a type I membrane-spanning sequence at their C termini rather than glycosylphosphatidylinositol anchor sequences. RAET1E is a Fn ligand for NKG2D, which causes lymphocyte activation resulting in the secretion of cytokines.

Application Details

  • Application: ELISA ; FACS ; IF ; IP ; Fn ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Cao et al. 2007. J Biol Chem. 282(26):18922-8. PMID: 17470428.
  • •  RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity.
  • •  Bacon et al. 2004. J Immunol. 173(2):1078-84. PMID: 15240696.
  • •  Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D.
  • •  Chalupny et al. 2003. Biochem Biophys Res Commun. 305(1):129-35. PMID: 12732206.
  • •  ULBP4 is a novel ligand for human NKG2D.