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Contributor Information

  • Name Helen Turley
  • Institute University of Oxford

Tool Details

  • Tool name: Anti-HIF1A [Hif28b]
  • Clone: Hif28b
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; IHC
  • Strain: Balb/c
  • Description: Induction of the Hif regulated genes, as a consequence of the microenvironment or genetic changes, is known to have an important role in the growth of experimental tumours. HIF1A has been observed in varying subsets of tumour cells from various solid tumours.
  • Immunogen: Immunogen containing human HIF1A amino acids 329-530.
  • Isotype: IgG1
  • Research area: Cancer; Genetics
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: Hypoxia-inducible factor 1, alpha subunit (HIF1A)
  • Target background: Induction of the Hif regulated genes, as a consequence of the microenvironment or genetic changes, is known to have an important role in the growth of experimental tumours. HIF1A has been observed in varying subsets of tumour cells from various solid tumours.

Application Details

  • Application: ELISA ; IHC

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Giatromanolaki et al. 2003. J Pathol. 200(2):222-8. PMID: 12754744.
  • •  DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer.
  • •  Hui et al. 2002. Clin Cancer Res. 8(8):2595-604. PMID: 12171890.
  • •  Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival.
  • •  Beasley et al. 2002. Cancer Res. 62(9):2493-7. PMID: 11980639.
  • •  Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients.
  • •  Talks et al. 2000. Am J Pathol. 157(2):411-21. PMID: 10934146.
  • •  The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.
  • •  Wiesener et al. 1998. Blood. 92(7):2260-8. PMID: 9746763.
  • •  Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.