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Contributor Information

  • Institute University of Cambridge

Tool Details

  • Tool name: Anti-RAET1E [RAET1E 79/6]
  • Alternate names: UL16 binding protein 4; NKG2D Ligand 4; Latel
  • Clone: RAET1E 79/6
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; FACS ; IF ; IP ; Fn ; WB
  • Description: RAET1E (Retinoic Acid Early Transcript 1E), or ULBP4, is a member of the RAET1 family of major histocompatibility complex (MHC) class I-related genes. RAET1E and RAET1G differ from the other RAET1 proteins by having a type I membrane-spanning sequence at their C termini rather than glycosylphosphatidylinositol anchor sequences. RAET1E is a functional ligand for NKG2D, which causes lymphocyte activation resulting in the secretion of cytokines.
  • Immunogen: Recombinant protein of human RAET1E protein produced in E.coli with a N terminal 6x His tag
  • Isotype: IgG1 kappa
  • Research area: Immunology

  • For Research Use Only

Target Details

  • Target: RAET1E
  • Target background: RAET1E (Retinoic Acid Early Transcript 1E), or ULBP4, is a member of the RAET1 family of major histocompatibility complex (MHC) class I-related genes. RAET1E and RAET1G differ from the other RAET1 proteins by having a type I membrane-spanning sequence at their C termini rather than glycosylphosphatidylinositol anchor sequences. RAET1E is a Fn ligand for NKG2D, which causes lymphocyte activation resulting in the secretion of cytokines.

Application Details

  • Application: ELISA ; FACS ; IF ; IP ; Fn ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  McGilvray et al. 2010. Int J Cancer. 127(6):1412-20. PMID: 20054857.
  • •  ULBP2 and RAET1E NKG2D ligands are independent predictors of poor prognosis in ovarian cancer patients.
  • •  Ohashi et al. 2010. J Biol Chem. 285(22):16408-15. PMID: 20304922.
  • •  Post-translational modification of the NKG2D ligand RAET1G leads to cell surface expression of a glycosylphosphatidylinositol-linked isoform.
  • •  Cao et al. 2007. J Biol Chem. 282(26):18922-8. PMID: 17470428.
  • •  RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity.
  • •  Eagle et al. 2006. Hum Immunol. 67(3):159-69. PMID: 16698438.
  • •  Regulation of NKG2D ligand gene expression.
  • •  Bacon et al. 2004. J Immunol. 173(2):1078-84. PMID: 15240696.
  • •  Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D.
  • •  Chalupny et al. 2003. Biochem Biophys Res Commun. 305(1):129-35. PMID: 12732206.
  • •  ULBP4 is a novel ligand for human NKG2D.
  • •  Radosavljevic et al. 2002. Genomics. 79(1):114-23. PMID: 11827464.
  • •  A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3.