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Contributor Information

  • Name Alison Goodall
  • Institute University College London (UCL)

Tool Details

  • Tool name: Anti-Factor VII [RFF-VII/1]
  • Clone: RFF-VII/1
  • Tool type: Antibodies
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; Fn ; WB
  • Description: Factor VII is a 50kDa multi-domain, single chain plasma glycoprotein synthesised in the liver. It is essential for blood coagulation. Factor VII is converted to the active, two chain, serine protease Factor VIIa via cleavage by thrombin, factor Xa, factor IXa or factor XIIa. Factor VIIa converts factor X to factor Xa, which in turn converts prothrombin to thrombin. This monoclonal antibody partially inhibits human Factor VII activity.
  • Immunogen: Purified human factor VII
  • Isotype: IgG1 kappa
  • Research area: Tissue-specific biology
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: Factor VII
  • Target background: Factor VII is a 50kDa multi-domain, single chain plasma glycoprotein synthesised in the liver. It is essential for blood coagulation. Factor VII is converted to the active, two chain, serine protease Factor VIIa via cleavage by thrombin, factor Xa, factor IXa or factor XIIa. Factor VIIa converts factor X to factor Xa, which in turn converts prothrombin to thrombin. This monoclonal antibody partially inhibits human Factor VII activity.

Application Details

  • Application: ELISA ; Fn ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   Takase et al. 1988. J Clin Pathol. 41(3):342-5. PMID: 3360958.
  •   Takase et al. 1988. J Clin Pathol. 41(3):337-41. PMID: 3360957.
  •   Monoclonal antibodies to human factor VII: production of immunodepleted plasma for VII:C assays.
  •   Monoclonal antibodies to human factor VII: a one step immunoradiometric assay for VII:Ag.