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Contributor Information

  • Name Alison Goodall
  • Institute University College London (UCL)

Tool Details

  • Tool name: Anti-Factor VIII [RFF-VIII:c/8]
  • Clone: RFF-VIII:c/8
  • Tool type: Antibodies
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: IF ; Fn ; WB
  • Description: The commonest severe congenital bleeding disorder in all races is haemophilia A. The characteristic defect is a lack of coagulation factor VIII:C. Factor VIII:C is a glycoprotein that functions as a cofactor for factor IXa which, in the presence of calcium and phospholipids, converts factor X to the activated form Xa. This antibody binds to human FVIII:C heavy chain and inhibits its function.
  • Immunogen: Purified human factor VIII
  • Isotype: IgG1 kappa
  • Research area: Tissue-specific biology
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: Factor VIII
  • Target background: The commonest severe congenital bleeding disorder in all races is haemophilia A. The characteristic defect is a lack of coagulation factor VIII:C. Factor VIII:C is a glycoprotein that functions as a cofactor for factor IXa which, in the presence of calcium and phospholipids, converts factor X to the activated form Xa. This antibody binds to human FVIII:C heavy chain and inhibits its function.

Application Details

  • Application: IF ; Fn ; WB

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Takase et al. 1987. Br J Haematol. 66(4):497-502. PMID: 3117089.
  • •  Production of factor VIII deficient plasma by immunodepletion using three monoclonal antibodies.
  • •  Goodall et al. 1985. Thromb Haemost. 54(4):878-91. PMID: 3937279.
  • •  Registry of monoclonal antibodies to factor VIII and von Willebrand factor. International Committee on Thrombosis and Haemostasis.
  • •  Rotblat et al. 1985. Biochemistry. 24(16):4294-300. PMID: 2413885.
  • •  Purification of human factor VIII:C and its characterization by Western blotting using monoclonal antibodies.
  • •  Vehar et al. 1984. Nature. 312(5992):337-42. PMID: 6438527.
  • •  Structure of human factor VIII.
  • •  Rotblat et al. 1983. J Lab Clin Med. 101(5):736-46. PMID: 6403638.
  • •  Monoclonal antibodies to human procoagulant factor VIII.