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Contributor Information

  • Name Sharon Tooze
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-ATG9 [Atg9 14F2 8B1]
  • Clone: Atg9 14F2 8B1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Mouse ; Rat
  • Host: Hamster
  • Molecular weight of the target: 105 kDa
  • Application: IHC ; IP ; ELISA ; IHC ; IF ; IP ; WB
  • Strain: Armenian
  • Description: Autophagy is an important process associated with infectious disease, neurodegeneration, cancer and the maintenance of cellular homeostasis. ATG9 is an essential component of the autophagy machinery and is found on autophagosomes. It is a multi-spanning membrane protein which makes it useful for sub-cellular localization studies. The detection of this protein provides important information about cell health and survival.
  • Immunogen: Conserved C-terminal synthetic peptide of Human ATG9 sequence
  • Isotype: IgG
  • Research area: Cancer; Tissue-specific biology; Cell signaling and signal transduction; Metabolism; Neurobiology; Biochemistry
  • Myeloma used: P3X63Ag8.653

  • For Research Use Only

Target Details

  • Target: Autophagy-related protein 9 (ATG9)
  • Target molecular weight: 105 kDa
  • Target background: Autophagy is an important process associated with infectious disease, neurodegeneration, cancer and the maintenance of cellular homeostasis. ATG9 is an essential component of the autophagy machinery and is found on autophagosomes. It is a multi-spanning membrane protein which makes it useful for sub-cellular localization studies. The detection of this protein provides important information about cell health and survival.

Application Details

  • Application: IHC ; IP ; ELISA ; IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.7 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  ATG9A shapes the forming autophagosome through Arfaptin 2 and phosphatidylinositol 4-kinase III?
  • •  Chan et al. 2009. Mol Cell Biol. 29(1):157-71. PMID: 18936157.
  • •  Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism.
  • •  Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes.