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Contributor Information

  • Name David Becker
  • Institute University College London (UCL)

Tool Details

  • Tool name: Anti-Beta1 Connexin [2A]
  • Clone: 2A
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Chicken ; Human ; Mouse ; Rat
  • Host: Mouse
  • Molecular weight of the target: 46 kDa
  • Application: IHC ; IF ; WB
  • Description: Monoclonal antibody which detects connexin 32, linked to Charcot-Marie-Tooth disease.
  • Immunogen: The peptide, LEGHGDPLHLEE, was coupled at the C-terminal end to bovine thyroglobulin at a final molar ratio peptide:thyroglobulin of 4060:1.
  • Immunogen UniProt ID: P08034
  • Isotype: IgG
  • Research area: Cell signaling and signal transduction; Neurobiology
  • Myeloma used: P3X63Ag8.653

  • For Research Use Only

Target Details

  • Target: Connexin 32 (Cx32 or ?1)
  • Target molecular weight: 46 kDa
  • Target background: Connexins are a large family of proteins which form gap junctions. Gap junctions are cell membrane structures that facilitate direct cell-cell communication. Gap junctions are essential for various physiological processes, including coordinated depolarization of cardiac muscle, proper embryonic development, and the conducted response in microvasculature. Gap junction communication has been implicated in the patterning and development of vertebrate embryos. Individual connexins show complex spatial and temporal variation in expression patterns. This variation contributes to the control of intercellular signalling. Mutations in connexin 32 are linked to Charcot-Marie-Tooth disease X-linked type 1 (CMTX1), the most commonly inherited disorder of the peripheral nervous system.

Application Details

  • Application: IHC ; IF ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: Store at -20°C frozen. Avoid repeated freeze / thaw cycles
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Wright et al. 2001. Reproduction. 121(1):77-88. PMID: 11226030.
  • •  Stage-specific and differential expression of gap junctions in the mouse ovary: connexin-specific roles in follicular regulation.