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Contributor Information

  • Name Jonathon Pines
  • Institute University of Cambridge

Tool Details

  • Tool name: Anti-APC4 [CIV1.1]
  • Clone: CIV1.1
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 92 kDa
  • Application: IP ; IP ; WB
  • Description: APC4 is a component of the anaphase-promoting complex (APC). The APC complex functions as an ubiquitin ligase which promotes the transition from metaphase to anaphase of the cell cycle. APC4 contains WD repeats and has a molecular weight of approximately 92 kD. APC4 is located in the nucleus during interphase and at the centrosome during metaphase/anaphase.
  • Immunogen: C-terminus of APC4
  • Isotype: IgG
  • Research area: Cell biology; Biochemistry

  • For Research Use Only

Target Details

  • Target: Anaphase-promoting complex (APC) 4
  • Target molecular weight: 92 kDa
  • Target background: APC4 is a component of the anaphase-promoting complex (APC). The APC complex functions as an ubiquitin ligase which promotes the transition from metaphase to anaphase of the cell cycle. APC4 contains WD repeats and has a molecular weight of approximately 92 kD. APC4 is located in the nucleus during interphase and at the centrosome during metaphase/anaphase.

Application Details

  • Application: IP ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -80°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Di Fiore et al. 2015. Dev Cell. 32(3):358-72. PMID: 25669885.
  • •  The ABBA motif binds APC/C activators and is shared by APC/C substrates and regulators.
  • •  Sedgwick et al. 2013. EMBO J. 32(2):303-14. PMID: 23288039.
  • •  Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex.