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Contributor Information

  • Name Madalena Tarsounas
  • Institute Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details

  • Tool name: Anti-Rad51C [MTA36]
  • Clone: MTA36
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Polyclonal
  • Conjugate: Unconjugated
  • Reactivity: Mouse
  • Host: Rabbit
  • Application: IP ; WB
  • Description: RAD51C is a RAD51 paralogue. Rad51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. RAD51C is also a component for the homologous recombination pathway of DNA repair.
  • Immunogen: Mouse n-terminal RAD51C peptide .
  • Research area: Genetics

  • For Research Use Only

Target Details

  • Target: Rad51C
  • Target background: RAD51C is a RAD51 paralogue. Rad51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. RAD51C is also a component for the homologous recombination pathway of DNA repair.

Application Details

  • Application: IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Badie et al. 2009. J Cell Biol. 185(4):587-600. PMID: 19451272.
  • •  RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation.