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Contributor Information

  • Institute University of Birmingham

Tool Details

  • Tool name: Anti-FCER2 [BU38]
  • Alternate names: Fc Fragment Of IgE Receptor II; Immunoglobulin E-Binding Factor; Lymphocyte IgE Receptor; Fc Epsilon Receptor II; CD23 Antigen; BLAST-2; CLEC4J; IGEBF; FCE2; C-Type Lectin Domain Family 4; Member; Immunoglobulin Epsilon-Chain; CD23
  • Clone: BU38
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: FACS ; IHC ; IF ; IP ; WB
  • Description: Fc epsilon RII (CD23), a low-affinity IgE receptor, is widely expressed on the surface of a number of cell types. Fc epsilon RII mediates numerous IgE-related immune responses. Both membrane and soluble Fc epsilon RII play important roles in allergic responses.
  • Immunogen: Full length native CD23 of human origin
  • Isotype: IgG1
  • Research area: Immunology; Stem cell biology
  • Myeloma used: NS0

  • For Research Use Only

Target Details

  • Target: Fc epsilon RII (FCER2, CD23)
  • Target background: Fc epsilon RII (CD23), a low-affinity IgE receptor, is widely expressed on the surface of a number of cell types. Fc epsilon RII mediates numerous IgE-related immune responses. Both membrane and soluble Fc epsilon RII play important roles in allergic responses.

Application Details

  • Application: FACS ; IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Aubry JP. et al. 1987. Leucocyte Typing III. Oxford University Press-Oxford, New York, Tokyo
  • •  Knapp W. et al. 1989. Leukocyte Typing IV. Oxford University Press
  • •  Leucocyte Typing VI, Garland Publishing (1998)
  • •  Schlossman S.F. et al. 1995. Leukocyte Typing V. Oxford University Press
  • •  Maeda et al. 2002. J Histochem Cytochem. 50(11):1475-86. PMID: 12417613.
  • •  Immunohistochemical recognition of human follicular dendritic cells (FDCs) in routinely processed paraffin sections.
  • •  Karagiannis et al. 2001. Immunology. 103(3):319-31. PMID: 11454061.
  • •  Endocytosis and recycling of the complex between CD23 and HLA-DR in human B cells.
  • •  Sancho et al. 2000. J Immunol. 165(7):3868-75. PMID: 11034393.
  • •  Fn analysis of ligand-binding and signal transduction domains of CD69 and CD23 C-type lectin leukocyte receptors.
  • •  Chen et al. 2000. Appl Immunohistochem Mol Morphol. 8(1):1-11. PMID: 10937042.
  • •  Classification of small B-cell lymphoid neoplasms using a paraffin section immunohistochemical panel.
  • •  Sano et al. 1999. Proc Assoc Am Physicians. 111(1):82-91. PMID: 9893160.
  • •  Upregulated surface expression of intracellularly sequestered Igepsilon receptors (FcepsilonRII/CD23) following activation in human peripheral blood eosinophils.
  • •  Kroft et al. 1998. Mod Pathol. 11(10):967-70. PMID: 9796724.
  • •  Evaluation of CD23 expression in paraffin-embedded gastric lymphomas of mucosa-associated lymphoid tissue.
  • •  Sarsfield et al. 1996. J Pathol. 180(1):18-25. PMID: 8943810.
  • •  Kumar et al. 1996. Mod Pathol. 9(9):925-9. PMID: 8878025.
  • •  Use of CD23 (BU38) on paraffin sections in the diagnosis of small lymphocytic lymphoma and mantle cell lymphoma.
  • •  A study of accessory cells in the acquired lymphoid tissue of helicobacter gastritis.
  • •  Bonnefoy et al. 1995. Curr Opin Immunol. 7(3):355-9. PMID: 7546400.
  • •  CD23 and B-cell activation.
  • •  Hardie et al. 1993. Eur J Immunol. 23(5):997-1004. PMID: 8477815.
  • •  Quantitative analysis of molecules which distinguish Fn compartments within germinal centers.
  • •  Murray et al. 1991. J Pathol. 165(2):125-8. PMID: 1744798.
  • •  CD23 expression in non-Hodgkin lymphoma: immunohistochemical demonstration using the antibody BU38 on paraffin sections.
  • •  Hellen et al. 1991. J Clin Pathol. 44(4):293-6. PMID: 1827636.
  • •  Immunohistochemical demonstration of CD23 expression on lymphocytes in rheumatoid synovitis.
  • •  Rowlands et al. 1990. J Pathol. 160(3):239-43. PMID: 2139890.
  • •  Immunohistochemical determination of CD23 expression in Hodgkin's disease using paraffin sections.