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Contributor Information

  • Name Ayham Alnabulsi
  • Institute Vertebrate Antibodies Limited

Tool Details

  • Tool name: Anti-TIMP2 [3A4]
  • Clone: 3A4
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Mouse ; Rat ; Zebrafish
  • Host: Mouse
  • Application: IHC ; ELISA ; IHC ; WB
  • Strain: Balb/c
  • Description: Matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix (ECM) in normal physiological processes as well as in disease processes. Tissue inhibitors of metalloproteinases (TIMPs) are the main physiological regulators of the MMPs. The TIMPs are secreted proteins that complex with individual MMPs and regulate the activity of specific MMPs. Together, the MMPs and TIMPs form a complex biological system strictly controlling degradation of ECM. The MMPs and TIMPs have a significant role in facilitating tumour invasion and metastasis. Expression of TIMP2 has been identified in individual studies as prognostic biomarkers in established and locally advanced colorectal cancer.
  • Immunogen: Ovalbumin-conjugated synthetic peptide; DSGNDIYGNPI
  • Isotype: IgG2b
  • Research area: Cell biology; Cancer; Tissue-specific biology; Cell signaling and signal transduction; Biochemistry
  • Myeloma used: P3X63Ag8.653

  • For Research Use Only

Target Details

  • Target: TIMP2 (tissue inhibitor of metalloproteinases 2)
  • Target background: Matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix (ECM) in normal physiological processes as well as in disease processes. Tissue inhibitors of metalloproteinases (TIMPs) are the main physiological regulators of the MMPs. The TIMPs are secreted proteins that complex with individual MMPs and regulate the activity of specific MMPs. Together, the MMPs and TIMPs form a complex biological system strictly controlling degradation of ECM. The MMPs and TIMPs have a significant role in facilitating tumour invasion and metastasis. Expression of TIMP2 has been identified in individual studies as prognostic biomarkers in established and locally advanced colorectal cancer.

Application Details

  • Application: IHC ; ELISA ; IHC ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -80°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Keren-Shaul et al. 2017. Cell. 169(7):1276-1290.e17. PMID: 28602351.
  • •  A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease.
  • •  Jeffery et al. 2009. Histopathology. 54(7):820-8. PMID: 19635101.
  • •  The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers.
  • •  Lyall et al. 2006. Clin Cancer Res. 12(4):1184-91. PMID: 16489072.
  • •  Profiling markers of prognosis in colorectal cancer.
  • •  Curran et al. 2004. Clin Cancer Res. 10(24):8229-34. PMID: 15623598.
  • •  Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers.
  • •  Murray et al. 1998. Gut. 43(6):791-7. PMID: 9824606.
  • •  Matrix metalloproteinases and their inhibitors in gastric cancer.