ANTIBODIES
Contributor Information
- Name Jacqueline Cordell
- Institute University of Oxford
Tool Details
- Tool name: Anti-BCL2 [bcl-2/90]
- Clone: bcl-2/90
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: IHC ; WB
- Description: The pro-survival protein BCL2 derives its name from B-cell lymphoma 2, as it is the second member of a range of proteins initially described in chromosomal translocations involving chromosomes 14 and 18 in follicular lymphomas. Damage to the Bcl-2 gene has been identified as a cause of a number of cancers, including melanoma, breast, prostate, chronic lymphocytic leukemia, and lung cancer, and a possible cause of schizophrenia and autoimmunity. It is also a cause of resistance to cancer treatments.
- Immunogen: Synthetic peptide of amino acids 41-54 of human bcl-2 oncoprotein
- Isotype: IgG1
- Research area: Apoptosis and autophagy; Cancer; Cell signaling and signal transduction; Metabolism
- Myeloma used: P3/NS1/1-Ag4.1
- For Research Use Only
Target Details
- Target: Bcl2
- Target background: The pro-survival protein BCL2 derives its name from B-cell lymphoma 2, as it is the second member of a range of proteins initially described in chromosomal translocations involving chromosomes 14 and 18 in follicular lymphomas. Damage to the Bcl-2 gene has been identified as a cause of a number of cancers, including melanoma, breast, prostate, chronic lymphocytic leukemia, and lung cancer, and a possible cause of schizophrenia and autoimmunity. It is also a cause of resistance to cancer treatments.
Application Details
- Application: IHC ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15°C to -25°C
- Shipping conditions: Shipping at 4°C
Documentation
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