ANTIBODIES
Contributor Information
- Name Jacqueline Cordell
- Institute University of Oxford
Tool Details
- Tool name: Anti-Proliferation marker [JC1] mAb
- Clone: JC1
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Molecular weight of the target: 212 kDa and 123 kDa
- Application: IHC ; IF ; WB
- Description: JC1 detects a nuclear antigen, distinct from Ki67, present in proliferating cells. It is useful as a marker of proliferation in cases such as squamous cell carcinoma where the Ki67 index cannot be determined.
- Immunogen: Pokeweed-stimulated lymphocytes
- Isotype: IgG2a
- Research area: Cancer; Cell biology; Neurobiology
- Myeloma used: P3/NS1/1-Ag4.1
- For Research Use Only
Target Details
- Target: Proliferation marker
- Target molecular weight: 212 kDa and 123 kDa
Application Details
- Application: IHC ; IF ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
Documentation
Related Tools
References
- • Li et al. 2017. J Exp Clin Cancer Res. 36(1):58. PMID: 28427443.
- • Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2.
- • Wang et al. 2016. Am J Cancer Res. 6(6):1331-44. PMID: 27429847.
- • EMMPRIN, SP1 and microRNA-27a mediate physcion 8-O-?-glucopyranoside-induced apoptosis in osteosarcoma cells.
- • Zhang et al. 2016. J Med Chem. 59(7):3562-8. PMID: 27006991.
- • Unexpected Discovery of Dichloroacetate Derived Adenosine Triphosphate Competitors Targeting Pyruvate Dehydrogenase Kinase To Inhibit Cancer Proliferation.
- • Garrido et al. 1992. J Clin Pathol. 45(10):860-5. PMID: 1430255.
- • Monoclonal antibody JC1: new reagent for studying cell proliferation.
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