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Contributor Information

  • Name Julian Gannon
  • Institute Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details

  • Tool name: Anti-Plx [AZ44]
  • Alternate names: Polo Like Kinase 1; Serine/Threonine-Protein Kinase 13; EC 2.7.11.21; STPK13; PLK-1; Cell Cycle Regulated Protein Kinase; Polo Like Kinase; EC 2.7.11
  • Clone: AZ44
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Xenopus laevis
  • Host: Mouse
  • Application: WB ; ELISA ; WB
  • Strain: Balb/c
  • Description: Polo-like kinase (Plx) is a mitotic regulator conserved from yeasts to humans. Many key cell cycle regulators such as p53, cdc25, cyclin B and the Anaphase Promoting Complex are directly targeted by Plx.The Anaphase promoting complex is responsible for the destruction of cyclins and other proteins involved with mitosis.
  • Immunogen: Baculo expressed Polo-like-kinase from Xenopus laevis
  • Isotype: IgG1 kappa
  • Research area: Cell biology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Polo-like-kinase protein (Plk)
  • Target background: Polo-like kinase (Plx) is a mitotic regulator conserved from yeasts to humans. Many key cell cycle regulators such as p53, cdc25, cyclin B and the Anaphase Promoting Complex are directly targeted by Plx.The Anaphase promoting complex is responsible for the destruction of cyclins and other proteins involved with mitosis.

Application Details

  • Application: WB ; ELISA ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Esmaili et al. 2010. Cell Cycle. 9(19):3913-20. PMID: 20935510.
  • •  Wu et al. 2009. Nat Cell Biol. 11(5):644-51. PMID: 19396163.