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Contributor Information

  • Name Stephen West
  • Institute Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details

  • Tool name: Anti-XRCC2 [XRCC2 7B7/3] mAb
  • Clone: XRCC2 7B7/3
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 33 kDa
  • Application: WB
  • Strain: Balb/c
  • Description: X-Ray Repair Cross Complementing 2 (XRCC2) is a RAD51 paralog. RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. XRCC2 is also a component of the homologous recombination pathway.
  • Immunogen: His-tagged human XRCC2
  • Isotype: IgG1
  • Research area: Microbiology; Genetics
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: XRay Repair Cross Complementing 2 (XRCC2)
  • Target molecular weight: 33 kDa
  • Target background: X-Ray Repair Cross Complementing 2 (XRCC2) is a RAD51 paralog. RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. XRCC2 is also a component of the homologous recombination pathway.

Application Details

  • Application: WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C

Documentation

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References

  • •  Masson et al. 2001. Genes Dev. 15(24):3296-307. PMID: 11751635.
  • •  Masson et al. 2001. Genes Dev. 15(24):3296-307. PMID: 11751635.
  • •  Identification and purification of two distinct complexes containing the five RAD51 paralogs.
  • •  Cartwright et al. 1998. Nucleic Acids Res. 26(13):3084-9. PMID: 9628903.
  • •  The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family.