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Contributor Information

  • Name Helen Hurst
  • Institute Queen Mary University of London

Tool Details

  • Tool name: Anti-AP2a [AP2a 8G8/5]
  • Clone: AP2a 8G8/5
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 50 kDa
  • Application: ChIP ; IHC ; WB
  • Strain: Balb/c
  • Description: AP-2 is a family of developmentally regulated transcription factors which also play a role in breast cancer and melanoma. AP-2?Ÿ may be important in cardiac and kidney development. The AP-2 transcription factors form the OB2 complex that has been shown to up-regulate c-erb-B2 transcription.
  • Immunogen: Bacterialy expressed AP-2a/AP-2g fusion protein.
  • Isotype: IgG1
  • Research area: Cancer; Tissue-specific biology; Genetics
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Activating Protein 2 (AP-2) alpha (Human)
  • Target molecular weight: 50 kDa
  • Target background: AP-2 is a family of developmentally regulated transcription factors which also play a role in breast cancer and melanoma. AP-2? may be important in cardiac and kidney development. The AP-2 transcription factors form the OB2 complex that has been shown to up-regulate c-erb-B2 transcription.

Application Details

  • Application: ChIP ; IHC ; WB

Handling

  • Format: Liquid
  • Concentration: 0.82 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Nordentoft et al. 2011. BMC Cancer. 11:135. PMID: 21489314.
  • •  Increased expression of transcription factor TFAP2a correlates with chemosensitivity in advanced bladder cancer.
  • •  Bennett et al. 2009. PLoS One. 4(9):e6931. PMID: 19742317.
  • •  AP-2alpha induces epigenetic silencing of tumor suppressive genes and microsatellite instability in head and neck squamous cell carcinoma.