Product Image

Contributor Information

  • Name Roland Wolf
  • Institute University of Dundee

Tool Details

  • Tool name: Anti-Cytochrome P450 4A1, 2C11 [Clo1]
  • Clone: Clo1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Rat
  • Host: Mouse
  • Molecular weight of the target: 51/51.5 kDa
  • Application: ELISA ; WB
  • Description: The CYP2 family are part of the microsomal drug metabolising system that is responsible for oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substances. The hepatic CYP4A enzymes are important fatty acid and prostaglandin omega-hydroxylases that are highly inducible by fibric acid hypolipidemic agents and other peroxisome proliferators. In humans, 4A1, 4A2, & 4A3 have been cloned from liver, kidney and testis and have been detected in renal, hepatic & brain microvessels.
  • Immunogen: Rat liver cytochrome P450 2C11 and 4A1
  • Isotype: IgG2b
  • Research area: Cancer; Tissue-specific biology; Cell signaling and signal transduction; Metabolism

  • For Research Use Only

Target Details

  • Target: Cytochromes P450 4A1, 2C11. CYP4A1, CYP2C11
  • Target molecular weight: 51/51.5 kDa
  • Target background: The CYP2 family are part of the microsomal drug metabolising system that is responsible for oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substances. The hepatic CYP4A enzymes are important fatty acid and prostaglandin omega-hydroxylases that are highly inducible by fibric acid hypolipidemic agents and other peroxisome proliferators. In humans, 4A1, 4A2, & 4A3 have been cloned from liver, kidney and testis and have been detected in renal, hepatic & brain microvessels.

Application Details

  • Application: ELISA ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

Related Tools

Product Image

Anti-Estradiol immuno complex [C6] rAb

#157721
Product Image

Anti-integrin a4 [P4G9]

#161660
Product Image

Anti-IgD [V88P3F7*D2]

#152778

References

  • •  "Monoclonal Antibodies Diagnostics for Individual Members of the Cytochromes P450IV Gene Family", Abstract 1.36 at the 12th Eur. Work. on Drug Metabolism, Basel, Switzerland, Sept. 16-21, 1990.
  • •  "Monoclonal Antibodies Diagnostics for Individual Members of the Cytochromes P450IV Gene Family", Abstract 205 at the VIIIth Inter. Symp. on Microsomes and Drug Oxidations, Stockholm, Sweden, June 25-26, 1990.
  • •  Tzeng et al. 2012. Evid Based Complement Alternat Med. 2012:827278. PMID: 22253647.
  • •  Vinegar-Baked Radix Bupleuri Regulates Lipid Disorders via a Pathway Dependent on Peroxisome-Proliferator-Activated Receptor-a in High-Fat-Diet-Induced Obese Rats.