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Contributor Information

  • Name Bill Gullick
  • Institute Imperial Cancer Research Fund

Tool Details

  • Tool name: Anti-ErbB4 [HFR1]
  • Clone: HFR1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Mouse
  • Host: Mouse
  • Application: FACS ; IHC ; IF ; IP ; WB
  • Strain: Balb/c
  • Description: The EGFR family of type I growth factor receptor tyrosine kinases includes EGFR (HER1), c-erbB2 (HER2; neu), c-erbB3 (HER3) and c-erbB4 (HER4). c-erbB4 is involved in cell growth regulation and its expression or function may be altered in human cancers.
  • Immunogen: Synthetic peptide sequence RSTLQHPDYLQEYST from the cytoplasmic domain of the protein (residues 1249-1264.)
  • Isotype: IgG2b
  • Research area: Cancer; Cell biology; Cell signaling and signal transduction
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: ErbB4 (Her4, p180erbB4)
  • Target background: The EGFR family of type I growth factor receptor tyrosine kinases includes EGFR (HER1), c-erbB2 (HER2; neu), c-erbB3 (HER3) and c-erbB4 (HER4). c-erbB4 is involved in cell growth regulation and its expression or function may be altered in human cancers.

Application Details

  • Application: FACS ; IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Cystatin M loss is associated with the losses of estrogen receptor, progesterone receptor, and HER4 in invasive breast cancer.
  • •  Ko et al. 2010. Breast Cancer Res. 12(6):R100. PMID: 21092257.
  • •  Gulati et al. 2010. Diagn Pathol. 5:18. PMID: 20331873.
  • •  Overexpression of c-erbB2 is a negative prognostic factor in anaplastic astrocytomas.
  • •  Sundvall et al. 2007. Oncogene. 26(48):6905-14. PMID: 17486069.
  • •  Differential nuclear localization and kinase activity of alternative ErbB4 intracellular domains.
  • •  Carn et al. 2005. Mol Cancer Ther. 4(2):243-55. PMID: 15713896.
  • •  H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent.
  • •  Srinivasan et al. 1998. J Pathol. 185(3):236-45. PMID: 9771476.
  • •  Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types.