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Contributor Information

  • Name Helen Turley
  • Institute University of Oxford

Tool Details

  • Tool name: Anti-HIF1A [Ha111a]
  • Clone: Ha111a
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; IHC ; WB
  • Description: Induction of the Hif regulated genes, as a consequence of the microenvironment or genetic changes, is known to have an important role in the growth of experimental tumours. HIF1A has been observed in varying subsets of tumour cells from various solid tumours.
  • Immunogen: GST-human HIF1A amino acids 329-530 fusion protein
  • Isotype: IgG2a
  • Research area: Cancer; Genetics
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: Hypoxia-inducible factor 1, alpha subunit (HIF1A)
  • Target background: Induction of the Hif regulated genes, as a consequence of the microenvironment or genetic changes, is known to have an important role in the growth of experimental tumours. HIF1A has been observed in varying subsets of tumour cells from various solid tumours.

Application Details

  • Application: ELISA ; IHC ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   Andr et al. 2008. J Biol Chem. 283(43):29375-84. PMID: 18694926.
  •   Identification of an alternative mechanism of degradation of the hypoxia-inducible factor-1alpha.
  •   Wiesener et al. 1998. Blood. 92(7):2260-8. PMID: 9746763.
  •   Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.