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Contributor Information

  • Name Peter Beverley
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-CD14 [UCH-M1] mAb
  • Alternate names: CD14 Molecule; CD14 Antigen; Myeloid Cell-Specific Leucine-Rich Glycoprotein
  • Clone: UCH-M1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 52 kDa
  • Application: FACS ; IHC ; IF
  • Strain: Balb/c
  • Description: UCH-M1 can be used to investigate specific in vitro antibody responses to influenza virus by human lymphocytes.
  • Immunogen: Thymocytes and peripheral blood leucocytes (PBL)
  • Isotype: IgG2a
  • Research area: Tissue-specific biology; Cell biology; Immunology; Stem cell biology
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: CD14
  • Target molecular weight: 52 kDa
  • Target background: CD14 is found in human monocytes and vascular endothelium in some tissues. CD14 binds the endotoxin lipopolysaccharide.

Application Details

  • Application: FACS ; IHC ; IF

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Sadeghi et al. 2016. PLoS One. 11(10):e0162667. PMID: 27695085.
  • •  GM-CSF Down-Regulates TLR Expression via the Transcription Factor PU.1 in Human Monocytes.
  • •  Goya et al. 2006. Prostate. 66(15):1573-84. PMID: 16927388.
  • •  Prostate-specific antigen induces apoptosis of osteoclast precursors: potential role in osteoblastic bone metastases of prostate cancer.
  • •  Puig-Krger et al. 2004. J Biol Chem. 279(24):25680-8. PMID: 15070901.
  • •  Regulated expression of the pathogen receptor dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin in THP-1 human leukemic cells, monocytes, and macrophages.
  • •  Hogg et al. 1984. Immunology. 53(4):753-67. PMID: 6389324.
  • •  Monoclonal antibodies specific for human monocytes, granulocytes and endothelium.
  • •  Mitchell et al. 1983. Immunology. 50(2):239-50. PMID: 6578194.
  • •  Accessory cell and HLA compatibility requirements for the generation of specific in-vitro antibody responses to influenza virus by human blood lymphocytes.