ANTIBODIES

Contributor Information
- Institute University of Cambridge
Tool Details
- Tool name: Anti-HPV16E2 [TVG 261]
- Clone: TVG 261
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human papilloma virus
- Host: Mouse
- Cancer type: Gynaecologic cancer
- Application: IP ; WB ; ELISA ; IF ; WB
- Strain: Balb/c
- Description: TVG 261 is useful for detection of protein in cervical lesions.
- Immunogen: Vaccinia-E2 followed by intravenous injection of the maltose binding protein MBP-E2 (generated from an expression vector in which the E2 ORF was cloned in frame with malE).
- Isotype: IgG1
- Research area: Cancer; Microbiology
- Myeloma used: P3/NS1/1-Ag4.1
- For Research Use Only
Target Details
- Target: Human Papilloma virus-16 early protein 2 (HPV16 E2)
- Target background: The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. E1 and E2 are proteins involved in the regulation of viral DNA replication.
Application Details
- Application: IP ; WB ; ELISA ; IF ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15ðC to -25ðC
- Shipping conditions: Shipping at 4ðC
References
- • Evans et al. 2019. J Virol. 93(4):. PMID: 30518656.
- • Ludwig et al. 2018. Front Oncol. 8:445. PMID: 30370252.
- • Evans et al. 2017. Oncotarget. 8(47):81892-81909. PMID: 29137231.
- • Campos-Le
n et al. 2017. J Virol. 91(5):. PMID: 28031358. - • A deletion in the gene encoding the CD45 antigen in a patient with SCID.
- • A point mutation within CD45 exon A is the cause of variant CD45RA splicing in humans.
- • Hibma et al. 1995. Eur J Biochem. 229(2):517-25. PMID: 7744075.
- • The interaction between human papillomavirus type 16 E1 and E2 proteins is blocked by an antibody to the N-terminal region of E2.