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Contributor Information

  • Name Bill Gullick
  • Institute Imperial Cancer Research Fund

Tool Details

  • Tool name: Anti-ErbB3 [SGP1]
  • Clone: SGP1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: IP ; FACS ; IHC ; IF ; IP
  • Strain: Balb/c
  • Description: The EGFR family of type I growth factor receptor tyrosine kinases includes EGFR (HER1), c-erbB2 (HER2; neu), c-erbB3 (HER3) and c-erbB4 (HER4). c-erbB3 is normally found in non-dividing differentiated epithelial cells, neurones and hepatocytes. It has approximately 80% prevalence in a wide variety of tumours of the gastro-intestinal tract, and approximately 20% prevalence in breast cancer.
  • Immunogen: c-erb B3 protein from transfected human kidney fibroblasts purified by wheatgerm lectin affinity chromatography
  • Isotype: IgG1 kappa
  • Research area: Cancer; Cell biology; Cell signaling and signal transduction
  • Myeloma used: NS0

  • For Research Use Only

Target Details

  • Target: ErbB3 (Her3)
  • Target background: The EGFR family of type I growth factor receptor tyrosine kinases includes EGFR (HER1), c-erbB2 (HER2; neu), c-erbB3 (HER3) and c-erbB4 (HER4). c-erbB3 is normally found in non-dividing differentiated epithelial cells, neurones and hepatocytes. It has approximately 80% prevalence in a wide variety of tumours of the gastro-intestinal tract, and approximately 20% prevalence in breast cancer.

Application Details

  • Application: IP ; FACS ; IHC ; IF ; IP

Handling

  • Format: Liquid
  • Concentration: 0.82 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Vollmann-Zwerenz et al. 2010. Cytometry A. 77(4):387-98. PMID: 20151455.
  • •  Multichromatic phenotyping of HER receptor coexpression in breast tumor tissue samples using flow cytometry--possibilities and limitations.
  • •  Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types.
  • •  Rajkumar et al. 1994. Br J Cancer. 70(3):459-65. PMID: 8080731.
  • •  A monoclonal antibody to the human c-erbB3 protein stimulates the anchorage-independent growth of breast cancer cell lines.