ANTIBODIES

Contributor Information
- Name Bill Gullick
- Institute University College London (UCL)
Tool Details
- Tool name: Anti-ErbB3 [RTJ2]
- Clone: RTJ2
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; FACS ; IHC ; IF ; IP ; WB
- Description: The EGFR family of type I growth factor receptor tyrosine kinases includes EGFR (HER1), c-erbB2 (HER2; neu), c-erbB3 (HER3) and c-erbB4 (HER4). c-erbB3 is normally found in non-dividing differentiated epithelial cells, neurones and hepatocytes. It has approximately 80% prevalence in a wide variety of tumours of the gastro-intestinal tract, and approximately 20% prevalence in breast cancer.
- Immunogen: Synthetic peptide of human ErbB3
- Isotype: IgG1
- Research area: Cancer; Cell biology; Cell signaling and signal transduction
- Myeloma used: NS0
- For Research Use Only
Target Details
- Target: ErbB3 (Her3)
- Target background: The EGFR family of type I growth factor receptor tyrosine kinases includes EGFR (HER1), c-erbB2 (HER2; neu), c-erbB3 (HER3) and c-erbB4 (HER4). c-erbB3 is normally found in non-dividing differentiated epithelial cells, neurones and hepatocytes. It has approximately 80% prevalence in a wide variety of tumours of the gastro-intestinal tract, and approximately 20% prevalence in breast cancer.
Application Details
- Application: ELISA ; FACS ; IHC ; IF ; IP ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15ðC to -25ðC
- Shipping conditions: Shipping at 4ðC
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References
- • Almadori et al. 2010. Eur J Cancer. 46(6):1144-52. PMID: 20149638.
- • Anagnostou et al. 2010. Cancer Epidemiol Biomarkers Prev. 19(4):982-91. PMID: 20332259.
- • Analytic variability in immunohistochemistry biomarker studies.
- • Prognostic significance and clinical relevance of the expression of the HER family of type I receptor tyrosine kinases in human laryngeal squamous cell carcinoma.
- • Okwueze et al. 2007. J Invest Dermatol. 127(5):1030-41. PMID: 17124505.
- • Modulation of porcine wound repair with a transfected ErbB3 gene and relevant EGF-like ligands.
- • Srinivasan et al. 1998. J Pathol. 185(3):236-45. PMID: 9771476.
- • Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types.
- • Rajkumar et al. 1995. Int J Oncol. 6(1):105-9. PMID: 21556509.
- • Prevalence of C-erbb3 expression in squamous-cell carcinomas of the cervix as determined by the monoclonal-antibody rtj2.
- • Benterud et al. 1976. Tidsskr Nor Laegeforen. 96(31):1647-8. PMID: 982398.
- • [Hereditary angioneurotic edema]