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Contributor Information

  • Name Bill Gullick
  • Institute University College London (UCL)

Tool Details

  • Tool name: Anti-ErbB3 [RTJ2]
  • Clone: RTJ2
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; FACS ; IHC ; IF ; IP ; WB
  • Description: The EGFR family of type I growth factor receptor tyrosine kinases includes EGFR (HER1), c-erbB2 (HER2; neu), c-erbB3 (HER3) and c-erbB4 (HER4). c-erbB3 is normally found in non-dividing differentiated epithelial cells, neurones and hepatocytes. It has approximately 80% prevalence in a wide variety of tumours of the gastro-intestinal tract, and approximately 20% prevalence in breast cancer.
  • Immunogen: Synthetic peptide of human ErbB3
  • Isotype: IgG1
  • Research area: Cancer; Cell biology; Cell signaling and signal transduction
  • Myeloma used: NS0

  • For Research Use Only

Target Details

  • Target: ErbB3 (Her3)
  • Target background: The EGFR family of type I growth factor receptor tyrosine kinases includes EGFR (HER1), c-erbB2 (HER2; neu), c-erbB3 (HER3) and c-erbB4 (HER4). c-erbB3 is normally found in non-dividing differentiated epithelial cells, neurones and hepatocytes. It has approximately 80% prevalence in a wide variety of tumours of the gastro-intestinal tract, and approximately 20% prevalence in breast cancer.

Application Details

  • Application: ELISA ; FACS ; IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   Almadori et al. 2010. Eur J Cancer. 46(6):1144-52. PMID: 20149638.
  •   Anagnostou et al. 2010. Cancer Epidemiol Biomarkers Prev. 19(4):982-91. PMID: 20332259.
  •   Analytic variability in immunohistochemistry biomarker studies.
  •   Prognostic significance and clinical relevance of the expression of the HER family of type I receptor tyrosine kinases in human laryngeal squamous cell carcinoma.
  •   Okwueze et al. 2007. J Invest Dermatol. 127(5):1030-41. PMID: 17124505.
  •   Modulation of porcine wound repair with a transfected ErbB3 gene and relevant EGF-like ligands.
  •   Srinivasan et al. 1998. J Pathol. 185(3):236-45. PMID: 9771476.
  •   Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types.
  •   Rajkumar et al. 1995. Int J Oncol. 6(1):105-9. PMID: 21556509.
  •   Prevalence of C-erbb3 expression in squamous-cell carcinomas of the cervix as determined by the monoclonal-antibody rtj2.
  •   Benterud et al. 1976. Tidsskr Nor Laegeforen. 96(31):1647-8. PMID: 982398.
  •   [Hereditary angioneurotic edema]