ANTIBODIES
Contributor Information
- Institute Netherlands Cancer Institute
Tool Details
- Tool name: Anti-CD3 e [NKIT3a]
- Alternate names: CD3E; T-Cell Surface Glycoprotein CD3 Epsilon Chain
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: FACS ; IP
- Strain: Balb/c
- Description: The CD3-epsilon polypeptide together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause severe immunodeficiency.
- Immunogen: Human cytotoxic T-lymphocytes
- Isotype: IgG2b
- Research area: Cell signaling and signal transduction; Immunology
- Myeloma used: Sp2/0-Ag14
- For Research Use Only
Target Details
- Target: CD3 e
- Target background: The CD3-epsilon polypeptide together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause severe immunodeficiency.
Application Details
- Application: FACS ; IP
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15Ă°C to -25Ă°C
- Shipping conditions: Shipping at 4Ă°C
Documentation
Related Tools
References
- • Spits et al. 1983. Hybridoma. 2(4):423-37. PMID: 6332061.
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