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Contributor Information

  • Name Birgit Lane
  • Institute Queen Mary University of London

Tool Details

  • Tool name: Anti-Keratin7 [LP5K]
  • Clone: LP5K
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 54 kDa
  • Application: FACS ; IHC ; IF ; WB
  • Strain: Balb/c
  • Description: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 7 and 8 are two closely related type II keratins characteristic of simple epithelia. Keratin 7 is less widespread than keratin 8 and is expressed in sebaceous and sweat glands and some cells of the inner hair root sheath. Keratin 7 is often co-expressed with keratin 19.
  • Immunogen: Sonicated cytoskeleton fractions (insoluble in 1% Nonidet-P40) from SV40 transformed neonatal keratinocytes.
  • Isotype: IgG2b
  • Research area: Cell signaling and signal transduction
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Keratin 7
  • Target molecular weight: 54 kDa
  • Target background: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 7 and 8 are two closely related type II keratins characteristic of simple epithelia. Keratin 7 is less widespread than keratin 8 and is expressed in sebaceous and sweat glands and some cells of the inner hair root sheath. Keratin 7 is often co-expressed with keratin 19.

Application Details

  • Application: FACS ; IHC ; IF ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Lane EB et al. 1985. Ann. NY Acad. Sci. 455:241-58.PMID: 2417515
  • •  Sato et al. 2005. Blood. 106(2):428-35. PMID: 15797992.
  • •  Platelet-derived soluble factors induce human extravillous trophoblast migration and differentiation: platelets are a possible regulator of trophoblast infiltration into maternal spiral arteries.
  • •  Sato et al. 2003. Development. 130(22):5519-32. PMID: 14530297.
  • •  Trophoblasts acquire a chemokine receptor, CCR1, as they differentiate towards invasive phenotype.
  • •  Markey et al. 1991. J Invest Dermatol. 97(5):763-70. PMID: 1717607.
  • •  Expression of simple epithelial keratins 8 and 18 in epidermal neoplasia.