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Contributor Information

  • Name Birgit Lane
  • Institute Queen Mary University of London

Tool Details

  • Tool name: Anti-Keratin7 [LP1K]
  • Clone: LP1K
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Mammalian ; Xenopus laevis
  • Host: Mouse
  • Molecular weight of the target: 54 kDa
  • Application: IHC ; IF ; WB
  • Strain: Balb/c
  • Description: Monoclonal antibody which binds keratin 7.
  • Immunogen: Sonicated cytoskeleton fractions (insoluble in 1% Nonidet-P40) from SV40 transformed neonatal keratinocytes.
  • Immunogen UniProt ID: P08729
  • Isotype: IgG1
  • Research area: Cell signaling and signal transduction
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Keratin 7
  • Target molecular weight: 54 kDa
  • Target background: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 7 and 8 are two closely related type II keratins characteristic of simple epithelia. Keratin 7 is less widespread than keratin 8 and is expressed in sebaceous and sweat glands, blood vessels and some cells of the inner hair root sheath. Keratin 7 is often co-expressed with keratin 19. LP1K has some weak reactivity with keratin 8 and other type II keratins.

Application Details

  • Application: IHC ; IF ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: Store at -20°C frozen. Avoid repeated freeze / thaw cycles
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Lane EB et al. 1985. Ann. NY Acad. Sci. 455:241-58.PMID: 2417515
  • •  Reyes et al. 2018. J Oral Microbiol. 10(1):1374153. PMID: 29291034.
  • •  Yougbar et al. 2017. Nat Commun. 8(1):224. PMID: 28794456.
  • •  Devos et al. 2017. J Invest Dermatol. 137(2):494-505. PMID: 27725202.
  • •  Zhang et al. 2015. Reproduction. 150(2):139-49. PMID: 26021998.
  • •  Zhang et al. 2013. Cell Death Dis. 4:e502. PMID: 23429288.
  • •  CUL1 promotes trophoblast cell invasion at the maternal-fetal interface.
  • •  Zhang et al. 2012. PLoS One. 7(6):e38487. PMID: 22679510.
  • •  Expression of CD82 in human trophoblast and its role in trophoblast invasion.
  • •  Markey et al. 1992. Br J Dermatol. 126(2):154-60. PMID: 1371396.
  • •  Keratin expression in basal cell carcinomas.