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Contributor Information

  • Name Fiona Watt
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-Integrin a2 [HAS-3]
  • Alternate names: Integrin Subunit Alpha 2; Alpha 2 Subunit Of VLA-2 Receptor; Platelet Membrane Glycoprotein Ia; CD49 Antigen-Like Family Member B; Collagen Receptor; CD49B; GPIa; Very Late Activation Protein 2 Receptor, Alpha-2 Subunit; Human Platelet Alloantigen System 5; Platelet Glycoprotein GPIa; Platelet Antigen Br; VLA-2 Subunit Alpha; CD49b Antigen; HPA-5; VLA-2; VLAA2; BR
  • Clone: HAS-3
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: FACS ; IHC ; IF ; IP
  • Description: Monoclonal antibody which co-precipitates a2b1 integrin from keratinocytes and inhibits a2b1 motility in collagen.
  • Immunogen: Whole human keratinocytes.
  • Immunogen UniProt ID: P17301
  • Isotype: IgG2a
  • Research area: Cell biology; Cancer; Cell signaling and signal transduction; Metabolism
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Integrin a2 (CD49b)
  • Target background: Monoclonal antibody which co-precipitates a2b1 integrin from keratinocytes and inhibits a2b1 motility in collagen.

Application Details

  • Application: FACS ; IHC ; IF ; IP

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: Store at -20°C frozen. Avoid repeated freeze / thaw cycles
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Activation of c-MET induces a stem-like phenotype in human prostate cancer.
  • •  van Leenders et al. 2011. PLoS One. 6(11):e26753. PMID: 22110593.
  • •  Teklemariam et al. 2011. Toxicon. 57(5):646-56. PMID: 21255601.
  • •  Fn analysis of a recombinant PIII-SVMP, GST-acocostatin
  • •  an apoptotic inducer of HUVEC and HeLa, but not SK-Mel-28 cells.
  • •  Singh et al. 2010. Am J Physiol Lung Cell Mol Physiol. 299(2):L169-83. PMID: 20435685.
  • •  Can lineage-specific markers be identified to characterize mesenchyme-derived cell populations in the human airways?
  • •  Alford et al. 1998. J Cell Sci. 111 ( Pt 4):521-32. PMID: 9443900.
  • •  Integrin-matrix interactions affect the form of the structures developing from human mammary epithelial cells in collagen or fibrin gels.
  • •  Tenchini et al. 1993. Cell Adhes Commun. 1(1):55-66. PMID: 7521749.
  • •  Evidence against a major role for integrins in calcium-dependent intercellular adhesion of epidermal keratinocytes.