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Contributor Information

  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-EGFR [F4]
  • Clone: F4
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; FACS ; IHC ; IP ; RIA
  • Strain: Balb/c
  • Description: The EGFR family of type I growth factor receptor tyrosine kinases includes EGFR (HER1), c-erbB2 (HER2; neu), c-erbB3 (HER3) and c-erbB4 (HER4). Dysregulation of EGFR signaling as a consequence of overexpression, amplification and mutation of the EGFR gene occurs frequently in several types of cancers and many become dependent on EGFR signaling to maintain their malignant phenotypes.
  • Immunogen: Synthetic peptide (residues 985 to 996 of human EGFR) coupled to keyhole limpet hemocyanin.
  • Isotype: IgG1 kappa
  • Research area: Cancer; Cell signaling and signal transduction
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: Epidermal Growth Factor Receptor (EGFR, Her1)
  • Target background: The EGFR family of type I growth factor receptor tyrosine kinases includes EGFR (HER1), c-erbB2 (HER2; neu), c-erbB3 (HER3) and c-erbB4 (HER4). Dysregulation of EGFR signaling as a consequence of overexpression, amplification and mutation of the EGFR gene occurs frequently in several types of cancers and many become dependent on EGFR signaling to maintain their malignant phenotypes.

Application Details

  • Application: ELISA ; FACS ; IHC ; IP ; RIA

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Jaganathan et al. 2011. PLoS One. 6(5):e19605. PMID: 21573184.
  • •  A Fn nuclear epidermal growth factor receptor, SRC and Stat3 heteromeric complex in pancreatic cancer cells.
  • •  Gibson et al. 2009. PLoS One. 4(9):e7222. PMID: 19787046.
  • •  Roles of specific membrane lipid domains in EGF receptor activation and cell adhesion molecule stabilization in a developing olfactory system.
  • •  Berger et al. 1987. J Pathol. 152(4):297-307. PMID: 3668732.
  • •  Epidermal growth factor receptors in lung tumours.
  • •  Gullick et al. 1986. Cancer Res. 46(1):285-92. PMID: 2998607.
  • •  Expression of epidermal growth factor receptors on human cervical, ovarian, and vulval carcinomas.