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Contributor Information

  • Name Joyce Taylor-Papadimitriou
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-Integrin alpha 3 [F35 177-1]
  • Clone: F35 177-1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: IHC ; IF
  • Strain: Balb/c
  • Description: Integrins are heterodimeric cell surface receptors composed of a and b subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a3 is found on most cell types. Integrin a3 associates with b1 integrin to form integrin a3b1, which is one of the most abundant keratinocyte integrins and binds laminin 5.
  • Immunogen: MTSV1-7 HYE - human breast epithelial cells.
  • Isotype: IgG1 kappa
  • Research area: Cell biology; Cancer
  • Myeloma used: P3X63Ag8.653

  • For Research Use Only

Target Details

  • Target: Integrin a3 (CD49c)
  • Target background: Integrins are heterodimeric cell surface receptors composed of a and b subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a3 is found on most cell types. Integrin a3 associates with b1 integrin to form integrin a3b1, which is one of the most abundant keratinocyte integrins and binds laminin 5.

Application Details

  • Application: IHC ; IF

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Lustosa et al. 2014. ScientificWorldJournal. 2014:102541. PMID: 24737953.
  • •  Expression profiling using a cDNA array and immunohistochemistry for the extracellular matrix genes FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 in colorectal carcinoma progression and dissemination.
  • •  McInroy et al. 2011. Exp Cell Res. 317(17):2468-78. PMID: 21821021.
  • •  Plectin regulates invasiveness of SW480 colon carcinoma cells and is targeted to podosome-like adhesions in an isoform-specific manner.
  • •  Gaggioli et al. 2007. Nat Cell Biol. 9(12):1392-400. PMID: 18037882.
  • •  Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells.